ArticleFunctional & integrative genomics2026
A preliminary single-cell map of endometriosis suggests roles for fibroblast metabolism and macrophage polarization in disease progression.
Article in Functional & integrative genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Gut microbiota dysbiosis in endometriosis: mechanistic insights and gut microbiota-targeted therapeutic strategies.Frontiers in microbiology · 2026Review
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Authors and funding
8 authors.
Funding
Abstract
Single-cell RNA sequencing (scRNA-seq) serves as a crucial tool for rapidly and accurately quantifying tissue heterogeneity and its associated biological significance within highly organized life systems. In this study, we utilized scRNA-seq to compare and analyze the characteristics of cell populations in eutopic endometrium (EUE) and its paired ectopic endometrium (ECE). Also, through multiple analytical approaches, we revealed the distinct contributions of fibroblasts and immune cells in endometriosis (EMs), with a particular focus on the features of fibroblasts and macrophages during pseudo-time differentiation. Notably, we not only identified Aquaporin 9-positive monocyte/macrophages (AQP9+/CD68+ cells) by anchoring the target protein AQP9 from the macrophage marker gene, but further quantitative analysis confirmed that AQP9 expression abundance was positively correlated with the disease stage of EMs (rASRM stage), i.e., the higher the disease stage, the higher the expression level of AQP9 in ectopic lesions. This suggests that AQP9 may be involved in the pathological progression of EMs, and its expression shows a preliminary association with disease severity. In summary, our results provide a high-resolution, preliminary cellular map of EMs, proposing novel hypotheses regarding disease progression mechanisms, and informing potential research priorities for future investigations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.