Evidence map›Paper›PMID 41912886›Full record

ReviewDie Ophthalmologie2026

[Diseases of the vitreoretinal interface : What role does the vitreous body play?]

Adrian Konstantin Luyken, H Faatz, C Lange, S K Boneva, F Schaub

Abstract readEnglish AbstractReview
PubMed Publisher
In one paragraph

Review in Die Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Adrian Konstantin LuykenKlinik und Poliklinik für Augenheilkunde, Universitätsmedizin Rostock, Doberaner Str. 140, 18057, Rostock, Deutschland. Adriankonstantin.luyken@med.uni-rostock.de.ORCID http://orcid.org/0009-0003-8618-556X
H FaatzAugenzentrum am St. Franziskus-Hospital Münster, Hohenzollernring 74, 48145, Münster, Deutschland.
C LangeAugenzentrum am St. Franziskus-Hospital Münster, Hohenzollernring 74, 48145, Münster, Deutschland.
S K BonevaKlinik für Augenheilkunde, Universitätsklinikum Freiburg, Freiburg, Deutschland.
F SchaubKlinik und Poliklinik für Augenheilkunde, Universitätsmedizin Rostock, Doberaner Str. 140, 18057, Rostock, Deutschland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Once viewed as an inert transparent medium with no pathophysiological importance, the vitreous body is now recognized as a dynamic, cell-regulated compartment with structural, mechanical, biological and immunological functions closely interacting with the retina. Hyalocytes, structural and cellular changes of the vitreous body and the vitreoretinal interface are central to many retinal diseases. Hyalocytes regulate the extracellular matrix and immune response and in cases of dysregulation promote proliferative processes. Structural phenomena, such as vitreoschisis and vitreous cortex remnants act as scaffolds for fibrocellular proliferation. Advances in optical coherence tomography (OCT) now enable a precise in vivo visualization of these mechanisms. This review article summarizes the current knowledge on the structure, cell biology and pathophysiology of the vitreous body, focusing on disorders such as vitreomacular traction (VMT), macular holes, epiretinal gliosis, proliferative vitreoretinopathy (PVR) and proliferative diabetic retinopathy (PDR). A better understanding of these mechanisms opens up new diagnostic and treatment approaches.

Indexed as

Eye DiseasesRetinal DiseasesVitreous BodyDiabetic RetinopathyHumansRetinaRetinal PerforationsTomography, Optical CoherenceVitreoretinopathy, ProliferativeVitreous DetachmentHyalocytesPosterior vitreous detachmentRetinal diseasesVitreoschisisVitreous cortex

Identifiers

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.