ArticleDoklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections2026
Calcium Signaling Modulator 4-MPTC Reduces Proliferative and Migration Activities of MDA-MB-468 Breast Cancer Cells.
Article in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cell malignant transformation is accompanied by a remodeling of various cell life-support systems, including calcium signaling. Modulation of the calcium signal can significantly sensitize cancer cells, making them more sensitive to anticancer drugs. A search for selective compounds that influence the cell calcium response is a promising area in the development of combination therapies for oncology diseases. The aim of this study was to determine the effect of 4-MPTC on the invasive potential of triple-negative breast cancer cells. 4-MPTC was previously selected as a modulator of the Stim2-dependent calcium entry pathway via a small molecule screening. 4-MPTC was shown to induce a massive calcium release from the intracellular calcium store in the endoplasmic reticulum (ER), blocks store-operated calcium entry, and reduces proliferation and migration activity of MDA-MB-468 triple-negative breast cancer cells.
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