Evidence map›Paper›PMID 41912752›Full record

ArticleMolecular neurobiology2026

Manganese Exposure: Delayed Effects and Biomarkers in adult male and female Wistar rats.

Tuany Eichwald, Diego Perinetto, Valéria Zardo, Karina Giacomini Varela, Analu Mantovani, Antuani Rafael Baptistella, Diego de Carvalho, Aline Pertile Remor

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tuany EichwaldLife Sciences Area, Postgraduate Program in Bioscience and Health (PPGBS), University of Western Santa Catarina (UNOESC), Joaçaba, SC, 89600-000, Brazil.
Diego PerinettoLife Sciences Area, Postgraduate Program in Bioscience and Health (PPGBS), University of Western Santa Catarina (UNOESC), Joaçaba, SC, 89600-000, Brazil.
Valéria ZardoBiological Sciences Degree, Life Sciences Area, University of Western Santa Catarina (UNOESC), Joaçaba, SC, Brazil.
Karina Giacomini VarelaLife Sciences Area, Postgraduate Program in Bioscience and Health (PPGBS), University of Western Santa Catarina (UNOESC), Joaçaba, SC, 89600-000, Brazil.
Analu MantovaniSoil Laboratory, University of Western Santa Catarina (UNOESC), Campos Novos, SC, Brazil.
Antuani Rafael BaptistellaLife Sciences Area, Postgraduate Program in Bioscience and Health (PPGBS), University of Western Santa Catarina (UNOESC), Joaçaba, SC, 89600-000, Brazil.
Diego de CarvalhoLife Sciences Area, Postgraduate Program in Bioscience and Health (PPGBS), University of Western Santa Catarina (UNOESC), Joaçaba, SC, 89600-000, Brazil.
Aline Pertile RemorLife Sciences Area, Postgraduate Program in Bioscience and Health (PPGBS), University of Western Santa Catarina (UNOESC), Joaçaba, SC, 89600-000, Brazil. aline.remor@unoesc.edu.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Manganese (Mn) is an essential trace element required for various physiological processes, but excessive exposure can lead to neurotoxicity and motor impairments. This study investigated the immediate and delayed behavioral effects and potential tissue biomarkers, as well as the immediate oxidative and metabolic alterations, following subacute Mn intoxication in adult male and female Wistar rats. Animals received MnCl₂ (15 mg/kg, intraperitoneally, for 5 days per week over 4 weeks, totaling 30 days of exposure). Following this treatment, animals were allocated into two independent experimental endpoints. The first group was evaluated immediately after the end of the 30-day MnCl

Indexed as

AgingBiomarkersManganeseAnimalsBrainFemaleMaleMotor ActivityOxidative StressRats, WistarTime FactorsBiomarkersManganeseDelayed effectsManganese neurotoxicityNon-invasive biomarkersOxidative and mitochondrial dysfunctionSex-dependent differences

Identifiers

PMID41912752
PMCPMC13035577

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.