ArticleThe Journal of antibiotics2026
Optical resolution of trichostatic acid using cinchonidine salts for the practical synthesis of trichostatin A enantiomers.
Article in The Journal of antibiotics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
In this study, optical resolution conditions using trichostatic acid as a key intermediate were investigated toward the practical supply of trichostatin A. Since previously reported asymmetric synthetic routes suffered from a decrease in optical purity upon scale-up, attention was focused on racemic trichostatic acid, and optical resolution via recrystallisation of cinchonidine salts was examined. As a result, selective access to both enantiomers was achieved depending on the solvent employed. The obtained optically active trichostatic acids were converted into trichostatin A according to known procedures, and the present method enabled the preparation of both enantiomers on a multi-gram scale.
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