Evidence map›Paper›PMID 41912604›Full record

ArticleScientific reports2026

MetaCAM as an ensemble-based class activation mapping framework improves model explainability.

Kevin Dick, Emily Kaczmarek, Olivier X Miguel, Alexa C Bowie, Robin Ducharme, Alysha L J Dingwall-Harvey, Steven Hawken, Christine M Armour, Mark C Walker

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kevin Dick *Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada. kdick@bornontario.ca.
Emily Kaczmarek *Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada.
Olivier X MiguelClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada.
Alexa C BowieClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada.
Robin DucharmeClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada.
Alysha L J Dingwall-HarveyChildren's Hospital of Eastern Ontario Research Institute, Ottawa, Canada.
Steven HawkenChildren's Hospital of Eastern Ontario Research Institute, Ottawa, Canada.
Christine M ArmourChildren's Hospital of Eastern Ontario Research Institute, Ottawa, Canada.
Mark C WalkerChildren's Hospital of Eastern Ontario Research Institute, Ottawa, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The need for clear, trustworthy explanations of deep learning model predictions is essential for high-criticality fields, such as medicine and biometric identification. Class Activation Maps (CAMs) are an increasingly popular category of visual explanation methods for Convolutional Neural Networks (CNNs). However, the performance of individual CAMs depends largely on experimental parameters such as the selected image, target class, and model. Here, we propose MetaCAM, an ensemble-based method for combining multiple existing CAM methods based on the consensus of the top-k% most highly activated pixels across component CAMs. We perform experiments to quantifiably determine the optimal combination of 11 CAMs for a given MetaCAM experiment. A new method denoted Cumulative Residual Effect (CRE) is proposed to summarize large-scale ensemble-based experiments. We also present adaptive thresholding and demonstrate how it can be applied to individual CAMs to improve their performance, measured using pixel perturbation method Remove and Debias (ROAD). Lastly, we show that MetaCAM outperforms existing CAMs and refines the most salient regions of images used for model predictions. In a specific example, MetaCAM improved ROAD performance to 0.393 compared to 11 individual CAMs with ranges from -0.101-0.172, demonstrating the importance of combining CAMs through an ensembling method and adaptive thresholding.

Indexed as

Class activation mapConvolutional neural networkEnsemble machine learningExplainable artificial intelligence

Identifiers

PMID41912604
PMCPMC13039914

What OpenQuestion holds

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.