Evidence map›Paper›PMID 41912597›Full record

ReviewNPJ microgravity2026

Anterior segment biomechanics and intraocular pressure in microgravity: implications for future spaceflight studies.

Alex Weaver, Joshua Ong, Baltaj S Sandhur, Ritu Sampige, Alexander Black, Andrew G Lee, John Berdahl, C Robert Gibson, Thomas H Mader

Abstract readReview
In one paragraph

Review in NPJ microgravity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alex WeaverDepartment of Ophthalmology, University of Florida College of Medicine, Jacksonville, FL, USA. Alex.weaver@jax.ufl.edu.
Joshua OngMichigan Medicine, University of Michigan, Ann Arbor, MI, USA.
Baltaj S SandhurJacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA.
Ritu SampigeBaylor College of Medicine, Houston, TX, USA.
Alexander BlackDepartment of Ophthalmology, University of Florida College of Medicine, Jacksonville, FL, USA.
Andrew G LeeCenter for Space Medicine, Baylor College of Medicine, Houston, TX, USA.
John BerdahlVance Thompson Vision, Sioux Falls, SD, USA.
C Robert GibsonNASA Johnson Space Center, Houston, TX, USA.
Thomas H MaderNASA Ophthalmology, Houston, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spaceflight acutely but transiently elevates intraocular pressure (IOP), often attributed to cephalad fluid shift and choroidal expansion. We propose that anterior segment mechanics, including lens-iris diaphragm position and conventional outflow loading, may contribute to early IOP changes. Comparing phakic and pseudophakic eyes, paired with anterior segment OCT and complementary imaging aboard the International Space Station, could define mechanisms and inform astronaut screening and ocular risk mitigation.

Identifiers

PMID41912597
PMCPMC13194981

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.