Evidence map›Paper›PMID 41912557›Full record

ArticleNPJ vaccines2026

Tracking spatio-temporal dynamics of early immune responses to an intranasal OMV-based pneumococcal vaccine candidate in mice.

Sajida Kanwal, Shaina Vivienne To, Rienke Uijen, Rona Roverts, Bram van Cranenbroek, Fred J van Opzeeland, Ben Joosten, Bart van den Berg van Saparoea, Christa E van der Gaast-de Jongh, Esther van Rijssen and 4 more

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Article in NPJ vaccines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sajida KanwalDepartment of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Center, Radboudumc Community for Infectious Diseases, Nijmegen, The Netherlands. Sajida.Kanwal@radboudumc.nl.
Shaina Vivienne ToElectron Microscopy Center, Radboud University Medical Center, Nijmegen, The Netherlands.
Rienke UijenDepartment of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Center, Radboudumc Community for Infectious Diseases, Nijmegen, The Netherlands.
Rona RovertsElectron Microscopy Center, Radboud University Medical Center, Nijmegen, The Netherlands.
Bram van CranenbroekDepartment of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Center, Radboudumc Community for Infectious Diseases, Nijmegen, The Netherlands.
Fred J van OpzeelandDepartment of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Center, Radboudumc Community for Infectious Diseases, Nijmegen, The Netherlands.
Ben JoostenElectron Microscopy Center, Radboud University Medical Center, Nijmegen, The Netherlands.
Bart van den Berg van SaparoeaAbera Bioscience AB, Uppsala, Sweden.
Christa E van der Gaast-de JonghDepartment of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Center, Radboudumc Community for Infectious Diseases, Nijmegen, The Netherlands.
Esther van RijssenDepartment of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Center, Radboudumc Community for Infectious Diseases, Nijmegen, The Netherlands.
Joen LuirinkAbera Bioscience AB, Uppsala, Sweden.
Dimitri A DiavatopoulosDepartment of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Center, Radboudumc Community for Infectious Diseases, Nijmegen, The Netherlands.
Lucille F van BeekDepartment of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Center, Radboudumc Community for Infectious Diseases, Nijmegen, The Netherlands.
Marien I de JongeDepartment of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Center, Radboudumc Community for Infectious Diseases, Nijmegen, The Netherlands. marien.dejonge@radboudumc.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Outer membrane vesicle (OMV)-based vaccines elicit strong immune responses and have emerged as a versatile platform for targeting multiple pathogens, yet the mechanisms underlying their efficacy remain incompletely understood. Here, we investigated the early immune response following intranasal administration of an OMV-based pneumococcal vaccine candidate in mice. Using in vivo bioluminescence imaging, spectral flow cytometry, and high-resolution microscopy, we tracked OMV biodistribution and immune activation throughout the respiratory tract from 1 to 72 h post-immunization. OMVs persisted in the nasal cavity for up to 48 h and rapidly recruited Ly6G

Identifiers

PMID41912557
PMCPMC13194884

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.