Evidence map›Paper›PMID 41912545›Full record

ArticleNature communications2026

In situ electrochemiluminescence microneedle device for real-time biomarker monitoring in vivo.

Huiwen Xiong, Chenxin Zhu, Ghazala Ashraf, Xiaopeng Guo, Lin Liu, Haonan Wang, Hui Chen, Wenhao Weng, Huali Shen, Jilie Kong and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Bioelectronic Considerations in Biomedical Microneedles.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Huiwen Xiong *Department of Chemistry, Fudan University, Shanghai, China.
Chenxin Zhu *Minhang Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Ghazala AshrafDepartment of Chemistry, Fudan University, Shanghai, China.
Xiaopeng GuoDepartment of Chemistry, Fudan University, Shanghai, China.
Lin LiuDepartment of Chemistry, Fudan University, Shanghai, China.
Haonan WangDepartment of Chemistry, Fudan University, Shanghai, China.
Hui ChenDepartment of Chemistry, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-2281-5935
Wenhao WengDepartment of Clinical Laboratory, Institute of Pediatric Infection, Immunity, and Critical Care Medicine, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Huali ShenMinhang Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China. shenhuali@fudan.edu.cn.ORCID http://orcid.org/0000-0002-0255-3720
Jilie KongDepartment of Chemistry, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-0780-6715
Xueen FangDepartment of Chemistry, Fudan University, Shanghai, China. fxech@fudan.edu.cn.ORCID http://orcid.org/0000-0002-3266-7868

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22374029, 22174024, 22174022, 22127806, 82472962, 82272174, 81827901
6 · The paper itself

Abstract

Continuous in vivo monitoring of biomarkers remains challenging due to limited sensitivity, integration, and biocompatibility. Here, we report an integrated microneedle-based electrochemiluminescence device (MN-ECLD) for real-time detection of protein biomarkers in interstitial fluid. Leveraging hydrogen-bonded organic frameworks with ultrabright, biocompatible electrochemiluminescence, the emitters were incorporated into porous gold-coated microneedle arrays and regulated via interface-specific Y-shaped probes, enabling efficient coreactant-free signal generation. The device achieved ultrasensitive protein detection in vitro with a linear range of 100 fg/mL to 10 ng/mL, a detection limit of 21.3 fg/mL, and stability over 12 days, delivering an 87-fold sensitivity enhancement over conventional emitters. In vivo, MN-ECLD enabled real-time monitoring of cardiac biomarkers, achieving early warning of acute myocardial infarction in rats and pigs, with biomarker trends consistent with serum ELISA. This work establishes a versatile platform for continuous in vivo diagnostics of acute cardiovascular and metabolic disorders.

Indexed as

BiomarkersElectrochemical TechniquesLuminescent MeasurementsMyocardial InfarctionAnimalsGoldLimit of DetectionNeedlesRatsSwineBiomarkersGold

Identifiers

PMID41912545
PMCPMC13376637

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.