Evidence map›Paper›PMID 41912536›Full record

ArticleNature communications2026

Lymphodepleting preconditioning impairs host antitumor immunity induced by adoptive T cell therapy in mouse models.

Diego Figueroa, Juan Pablo Vega, Andrés Hernández-Oliveras, Felipe Ardiles, Sofía Hidalgo, Ximena López, Vicente Saavedra, Catalina Bustamante, Daniela Malavé, Felipe Flores and 7 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Diego FigueroaCentro Basal Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile.
Juan Pablo VegaCentro Basal Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile.ORCID 0009-0003-1480-9783
Andrés Hernández-OliverasCentro Basal Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile.
Felipe ArdilesCentro Basal Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile.
Sofía HidalgoCentro Basal Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile.ORCID 0009-0009-6516-0957
Ximena LópezCentro Basal Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile.
Vicente SaavedraCentro Basal Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile.
Catalina BustamanteCentro Basal Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile.
Daniela MalavéCentro Basal Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile.
Felipe FloresLaboratory of Immunology and Cellular Stress, Facultad de Medicina, Universidad de Chile, Santiago, Chile.ORCID 0000-0002-6916-3962
Felipe Gálvez-CancinoLaboratory of Immune Regulation, NDM Centre for Immuno-Oncology, University of Oxford, Oxford, UK.ORCID 0000-0001-8417-1891
Hugo GonzalezCentro Basal Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile.
Manuel Varas-GodoyCentro Basal Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile.ORCID 0000-0001-5857-4793
Maria Rosa BonoCentro Basal Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile.ORCID 0000-0001-9318-343X
Fabiola OsorioCentro Basal Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile.
Vincenzo BorgnaCentro Basal Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile. vincenzo.borgna@uss.cl.
Alvaro LladserCentro Basal Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile. alladser@cienciavida.org.ORCID 0000-0002-5576-1478

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adoptive T cell therapy (ACT) is effective against hematologic cancers, but the mechanisms underlying durable responses in solid tumors remain unclear. We show that adoptively transferred CD8

Indexed as

CD8-Positive T-LymphocytesImmunotherapy, AdoptiveLymphocyte DepletionAnimalsCell Line, TumorDendritic CellsDisease Models, AnimalFemaleHumansMiceMice, Inbred C57BLTumor Necrosis Factor-alphaTumor Necrosis Factor-alpha

Identifiers

PMID41912536
PMCPMC13172322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.