Evidence map›Paper›PMID 41912509›Full record

ArticleNature communications2026

Spatial single cell transcriptomic analysis informs tumor developmental hierarchy of DICER1 syndrome related sarcoma.

Felix K F Kommoss, Joyce Yu Han Zhang, Branden J Lynch, Shary Yuting Chen, Janine Senz, Yana Moscovitz, Lesley A Hill, Ding Ma, R Wilder Scott, Jonathan Bush and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Felix K F Kommoss *Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Joyce Yu Han Zhang *Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0002-7289-6331
Branden J Lynch *Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.ORCID http://orcid.org/0009-0008-4564-8894
Shary Yuting ChenDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Janine SenzDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Yana MoscovitzDepartment of Basic and Translational Research, British Columbia Cancer Research Institute, Vancouver, BC, Canada.
Lesley A HillDepartment of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0001-6609-1935
Ding MaDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
R Wilder ScottBiological Sciences Platform, Holland Bone and Joint Program, Sunnybrook Research Institute, Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-7608-7489
Jonathan BushDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0001-9432-2390
Kenneth S ChenDepartment of Pediatrics, Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0003-2304-4631
Andrew RothDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0003-3422-8823
Andreas von DeimlingDepartment of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-5863-540X
William D FoulkesDepartment of Human Genetics, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0001-7427-4651
Gregg B MorinDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0001-8949-4374
T Michael UnderhillDepartment of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0003-3048-9102
Yemin WangDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada. yemin.wang@ubc.ca.ORCID http://orcid.org/0000-0002-2970-9510
David G HuntsmanDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada. dhuntsma@bccancer.bc.ca.ORCID http://orcid.org/0000-0003-4934-3322

Funding

Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) PJT#195754, PJT#178179Terry Fox Research Institute (Institut de Recherche Terry Fox) #1082 and #1155
6 · The paper itself

Abstract

DICER1-related tumor predisposition (DRTP), also known as DICER1 syndrome, encompasses a spectrum of malignancies mainly in children and young adults. Most are sarcomas, exhibiting histological and molecular similarities regardless of their anatomical origins, and only express the RNase IIIb domain-defective DICER1. To uncover their cellular origin and developmental hierarchy, we establish a lineage-traceable genetically engineered mouse model with controlled activation of hemizygous Dicer1 RNase IIIb mutation in Hic1

Indexed as

DEAD-box RNA HelicasesKidney NeoplasmsRibonuclease IIISarcomaAnimalsDisease Models, AnimalFemaleFibroblastsGene Expression ProfilingHumansMesenchymal Stem CellsMiceMice, TransgenicMutationSingle-Cell AnalysisSingle-Cell Gene Expression AnalysisDEAD-box RNA HelicasesDICER1 protein, humanDicer1 protein, mouseRibonuclease III

Identifiers

PMID41912509
PMCPMC13199431

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.