ArticleTranslational psychiatry2026
rTMS for rapid relief of sleep disorders induced by influenza virus infection: a clinical retrospective study.
Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
To explore the effect of repetitive transcranial magnetic stimulation (rTMS) on influenza-induced sleep disorders, verify its adjuvant value, and reveal the "influenza-immune inflammation-abnormal brain function-sleep disorder" pathway, a retrospective cohort study enrolled 55 adults (18-40 years, no comorbidities) with acute influenza (2023-2025, First Affiliated Hospital of Air Force Medical University). They were divided into positive control group (PC, n = 20, conventional treatment) and rTMS group (n = 16, conventional + rTMS: 10 Hz, 1x/day, 20-30 mins, 3000 pulses, 100% motor threshold, 3 days; split into pre-treatment [BT-rTMS] and post-treatment [AT-rTMS] subgroups). Twenty healthy people served as negative controls group (NC). Assessments included polysomnography (PSG), Sleep Disorder-Visual Analog Scale (SD-VAS), functional near-infrared spectroscopy (fNIRS) for frontal oxygenated hemoglobin, and ELISA for 9 blood indicators. Two-sample Mendelian randomization (TSMR), ROC models, and t-tests (P < 0.05) were used. TSMR showed influenza correlated with insomnia (IVW:P = 0.047, 95% OR = 1.001-1.134) and 27 brain structural changes (frontal most affected, n = 10). Serum IgM (IVW:P = 0.048, 95% OR = 1.001-1.193) and neutrophils (IVW:P = 0.003, 95% OR = 1.018-1.089) mediated sleep disorders, linking to SD-VAS and frontal gray matter. Left inferior frontal gyrus and right orbital gyrus were key. BT-rTMS had abnormal sleep (duration/efficiency/stages) vs NC, with higher right orbitofrontal cortex (R-OFC) and left ventrolateral prefrontal cortex (L-VLPFC) oxygenated hemoglobin (P < 0.05). AT-rTMS improved sleep vs PC, with lower R-OFC/L-VLPFC oxygenated hemoglobin (P < 0.05). A 7-indicator ROC model had AUC = 0.8571. rTMS improves influenza-related sleep disorders short-term by inhibiting frontal overactivation (R-OFC, L-VLPFC) and regulating immunity (IgM,neutrophils), offering a safe, rapid new approach for acute influenza sleep management.
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