ArticleBlood cancer journal2026
Management of hematological toxicities after BCMA-directed CAR-T cell therapy.
Article in Blood cancer journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- CAR-HEMATOTOX score as a predictor of hematotoxicity, infection, and survival after CAR T-cell therapy in hematologic malignancies: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Pre-Infusion Host-Marrow Vulnerability in CD19- and BCMA-Directed CAR T-Cell Therapy: Clonal Hematopoiesis, Hematotoxicity, and Therapy-Related Myeloid Neoplasia.Cancer management and research · 2026Review
- Characteristics and research waste of immunotherapy randomized clinical trials: a cross-sectional analysis.Frontiers in immunology · 2026Article
Corrections and comments
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Authors and funding
29 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The CAR-HEMATOTOX (CAR-HT) score can assess hematotoxicity risk, but its utility in guiding supportive care remains underexplored. We analyzed 224 multiple myeloma patients treated with BCMA-directed CAR-T therapy (2016-2024), stratified by CAR-HT score (low <2 vs high ≥2). We evaluated the incidence and timing of early immune effector cell-associated hematotoxicity (ICAHT), other cytopenias, transfusion burden, cytopenia-directed interventions (growth factors and stem cell boosts), infections, and survival outcomes. High CAR-HT scores (58%) were associated with more grade 3 ICAHT (45.4% vs 23.3%) and grade 4 ICAHT (5.4% vs 1.2%; p = 0.0069), higher rates of grade ≥3 anemia (43.1% vs 24.4%, p < 0.0001) and thrombocytopenia (50.8% vs 27.9%, p < 0.0001). These patients were 7 times more likely to require red cell and platelet transfusions (p < 0.0001). G-CSF and TPO agonists were variably effective. Stem cell boosts (4%) led to rapid trilineage recovery. Infections occurred more frequently among high CAR-HT patients and those receiving intensive cytopenia-directed interventions. There were no significant differences in progression-free or overall survival between CAR-HT groups. Cytopenia-directed interventions did not affect survival. The CAR-HT score is a practical clinical risk tool that predicts transfusion burden and helps guide supportive care after BCMA CAR-T therapy.
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Registered trials
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