Evidence map›Paper›PMID 41912440›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2026

Lack of Cerebrospinal Fluid α-Synuclein Seeding in VPS35 D620N- and LRRK2 Y1699C-Linked Parkinson's Disease.

Letizia Santinelli, Neringa Pratuseviciute, Lara M Lange, Teresa Kleinz, Norbert Brüggemann, Linn Streubel-Gallasch, Meret Möller, Alexander Zimprich, Christof Brücke, Jean-Marc Good and 9 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Large-scale functional annotation establishes a reference framework for humanmedRxiv : the preprint server for health sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Letizia SantinelliInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.ORCID https://orcid.org/0009-0009-9220-0547
Neringa PratuseviciuteMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, United Kingdom.ORCID https://orcid.org/0000-0002-1124-8699
Lara M LangeInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Teresa KleinzInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.ORCID https://orcid.org/0009-0000-6313-7395
Norbert BrüggemannInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Linn Streubel-GallaschInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Meret MöllerInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Alexander ZimprichComprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Vienna, Austria.
Christof BrückeComprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Vienna, Austria.
Jean-Marc GoodDivision of Genetic Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Norman GriebnerSection for Movement Disorders, Department of Neurology, University of Lübeck, Lübeck, Germany.
Shalini PadmanabhanThe Michael J. Fox Foundation for Parkinson's Research, New York, New York, USA.
Philip SeiblerInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Peter BauerCENTOGENE GmbH, Rostock, Germany.
Wim VandenbergheLaboratory for Parkinson Research, Department of Neurosciences, Leuven, Belgium.
Esther SammlerMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, United Kingdom.ORCID https://orcid.org/0000-0003-3218-7116
Cornelis BlauwendraatLaboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0001-9358-8111
Christine KleinInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Max BorscheInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.ORCID https://orcid.org/0000-0002-9651-5986

Funding

Else Kröner-Fresenius-Stiftung 2023_EKEA.36Michael J. Fox Foundation for Parkinson's Research 023915
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

biomarkerkinase activityLRRK2 Y1699Cmonogenic Parkinson's diseaseSAAseed amplification assayVPS35 D620Nα‐synuclein

Identifiers

PMID41912440
PMCPMC13307260

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.