Evidence map›Paper›PMID 41912420›Full record

ArticleJournal of the National Cancer Institute2026

Use of low-value cancer care in practices acquired by private equity firms.

Aaron P Mitchell, Miranda B Lam, Caroline Carlin, Kevin Tyan, Maryam Mooghali, Ziad Zakaria, Reshma Ramachandran, Jeah Jung

Abstract read
In one paragraph

Article in Journal of the National Cancer Institute, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Aaron P MitchellDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, United States.ORCID 0000-0003-3639-3515
Miranda B LamDepartment of Radiation Oncology, Brigham and Women's Hospital, Boston, MA, United States.ORCID 0000-0001-7885-6317
Caroline CarlinDepartment of Family Medicine and Community Health, University of Minnesota, Minneapolis, MN, United States.ORCID 0000-0003-0813-3433
Kevin TyanDepartment of Medicine, Harvard Medical School, Boston, MA, United States.ORCID 0000-0002-8585-1802
Maryam MooghaliDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT, United States.ORCID 0000-0001-9347-494X
Ziad ZakariaDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Reshma RamachandranDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT, United States.ORCID 0000-0003-3845-3606
Jeah JungDepartment of Health Administration and Policy, College of Public Health, George Mason University, Fairfax, VA, United States.ORCID 0000-0001-7574-0677

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Resource Use and Quality of Care in Medicare AdvantageR01AG069352 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI JUNG, JEAH · 2020 to 2023
$2.7M
Memorial Sloan Kettering Cancer CenterNCI NIH HHS P30 CA008748NIA NIH HHS 1R01AG069352NIA NIH HHS 23 to 09258NIA NIH HHS 23 to 23507NIA NIH HHS R01 AG069352
6 · The paper itself

Abstract

Private equity acquisition of medical practices has been associated with increased prices and use of lucrative treatments. Using Medicare data from 2015 to 2021, we compared the prevalence of low-value cancer treatments between private equity-owned and non-private equity-owned practices. The 5 low-value treatments were (1) granulocyte colony-stimulating factors for low-risk chemotherapy, (2) denosumab for castration-sensitive prostate cancer, (3) nab-paclitaxel for breast or lung cancer, (4) the addition of bevacizumab for ovarian cancer, and (5) biologic agents with biosimilar alternatives. The primary outcome was receipt of a low-value treatment. Comparing patients diagnosed when their oncologist was vs was not practicing at a private equity-owned address, adjusted prevalence differences of low-value treatments were -2.8 percentage points (95% confidence interval [CI] = -5.5 to -0.2) for granulocyte colony-stimulating factors, +3.7 percentage points (95% CI = -7.3 to 14.7) for denosumab, -0.7 percentage points (95% CI = -3.9 to 1.5) for nab-paclitaxel, -6.5 percentage points (95% CI = -12.5 to -0.4) for bevacizumab, and -2.9 percentage points (95% CI = -6.0 to 0.2) for biologics. Overall, private equity ownership was not associated with increased prevalence of low-value cancer treatments.

Indexed as

NeoplasmsAgedBevacizumabDenosumabFemaleGranulocyte Colony-Stimulating FactorHumansMaleMedicareUnited StatesBevacizumabDenosumabGranulocyte Colony-Stimulating Factor

Identifiers

PMID41912420
PMCPMC13421076

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.