ArticleDermatology practical & conceptual2026
Genetic Polymorphisms of miR-146a and miR-155 in Psoriasis and Psoriatic Arthritis: Evidence from a Turkish Case-Control Study.
Article in Dermatology practical & conceptual, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Correction.Dermatology practical & conceptual · 2026Article
Corrections and comments
- Erratum issuedCorrection.2026
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPsoriasis, a widespread inflammatory cutaneous disease, is driven by an interplay of genetic and environmental risk factors. miR-155 and miR-146a have been implicated in the regulation of inflammatory pathways.
objectivesIn the current study, we examined the association between miR-155 rs767649 and miR-146a rs2910164 variants and the predisposition to psoriasis and psoriatic arthritis.
methodsA total of 544 individuals, including 284 psoriasis cases (68 with psoriatic arthritis) and 260 controls, were enrolled in the present study. Real-time polymerase chain reaction (qPCR) method was used to detect the genotypes of study groups.
resultsThe frequencies of the rs2910164 C allele, CC, and GC genotypes were significantly higher in the patient group (P<0.001), while the frequencies of the rs767649 A allele and AA genotype were higher in the control group (P=0.005 and P=0.002, respectively). No statistically significant difference in genotype or allele frequency was observed between patients with and without psoriatic arthritis (P>0.05). Rs2910164 CC and GC genotypes were found to be associated with a younger age at disease onset (P=0.006), and CC genotype was associated with higher PASI score (P=0.024).
conclusionThe present data suggest an association between the presence of the miR-155 rs767649 and miR-146a rs2910164 variants and susceptibility to psoriasis in the Turkish population. However, although the number of patients with psoriatic arthritis in our study was relatively small, no association was found between these variants and the development of psoriatic arthritis. Furthermore, the rs2910164 polymorphism was found to be associated with both early-onset disease and PASI score.
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