ArticleDermatology practical & conceptual2026
Association of Serum IgE and Peripheral Eosinophilia with Seborrheic Dermatitis: Evidence from a Case-Control Study.
Article in Dermatology practical & conceptual, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionIt is thought that some shared mechanisms may play a role in the pathophysiology of seborrheic dermatitis (SD) and atopic conditions, both of which are chronic, inflammatory, and recurrent in nature.
objectiveThis study aimed to investigate the presence of atopic diseases in SD patients without atopic dermatitis or other inflammatory skin disorders and to assess their serum IgE levels and peripheral eosinophil values as a marker of atopy.
methodsThis prospective cross-sectional study included 83 SD patients and 68 age- and sex-matched healthy controls.
resultsThere were no significant differences between the SD patients and the healthy control group regarding sex distribution (P=0.507) or mean age (P=0.436). No significant difference was observed between SD and control groups in terms of accompanying rhinitis, conjunctivitis, or asthma (P=0.307, P=0.487, and P=0.370, respectively). The median serum IgE levels were significantly higher in SD patients than in controls (123.1vs. 46.7; P=0.001) No significant difference was observed between the groups in terms of eosinophil percentage or absolute eosinophil count (P=0.678 and P=0.827, respectively). SD patients with concomitant rhinitis had significantly higher IgE levels than those without rhinitis (P=0.048).
conclusionIn this study, total serum IgE levels were significantly higher in SD patients than in healthy controls, suggesting that allergens and hypersensitivity responses may play a greater role in the pathogenesis of SD than previously thought.
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