ReviewDermatology practical & conceptual2026
Dermoscopy of Keratinizing Skin Tumors: Cutaneous Squamous Cell Carcinoma, Keratoacanthoma, and Bowen's Disease.
Review in Dermatology practical & conceptual, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
introductionCutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer, with incidence rising due to increased ultraviolet exposure, an aging population, and a growing number of immunocompromised individuals.
objectivesThis review presents a comprehensive analysis of dermoscopic features of cSCC lesions, delineating distinct patterns of Bowen's disease (BD) and invasive cSCC, including keratoacanthoma (KA). The primary outcome was the identification of dermoscopic patterns specific to cSCC, while the secondary endpoint involved determining the prevalence of these features across different subtypes.
methodsWe selected studies including individuals with histopathologically proven cSCC who underwent dermoscopic evaluation. Studies with at least five cases of cSCC were included, with no constraint on the study design.
resultsOur analysis reveals that BD typically exhibits white-to-yellow scales and glomerular vessels, whereas KA is characterized by a layered architecture with a central keratin plug, an ivory-white peripheral zone, and a symmetrical distribution of hairpin vessels. In contrast, invasive cSCC demonstrates a progression from well-differentiated lesions with organized vascular patterns to poorly differentiated forms marked by chaotic, polymorphic vessels and predominant red hues.
conclusionThese distinct dermoscopic patterns serve as practical clinical guides for differentiating SCC grades of invasion and differentiation, thereby enhancing diagnostic accuracy and patient management.
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Registered trials
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