Evidence map›Paper›PMID 41911483›Full record

ArticleJournal of proteome research2026

Microglial Adaptations to Chronic Nicotine in the Cerebellum: Proteomic Evidence for Neuroimmune Vulnerability.

Aya Nusir, Scott M Anthony, Weidong Zhou, Nadine Kabbani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of proteome research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aya NusirInterdisciplinary Program in Neuroscience, School of Systems Biology, George Mason University, Fairfax, Virginia 22030, United States.
Scott M AnthonyBiomedical Research Laboratory, George Mason University, 10650 Pyramid Place, Manassas, Virginia 20110, United States.
Weidong ZhouCenter for Applied Proteomics and Molecular Medicine, George Mason University, 10920 George Mason Circle, Manassas, Virginia 20110, United States.
Nadine KabbaniInterdisciplinary Program in Neuroscience, School of Systems Biology, George Mason University, Fairfax, Virginia 22030, United States.ORCID 0000-0001-5515-3782

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Smoking is a major public health concern with widespread effects on multiple organ systems, including the immune system. Chronic nicotine exposure can alter immune cell function through nicotinic receptors expressed on peripheral macrophages and microglia in the brain. Recent evidence indicates that the cerebellum is impacted by nicotine, contributing to motor and nonmotor outcomes, during drug use. In this study, we investigated the effect of chronic nicotine on microglia proteomes in the adult mouse cerebellum. Microglia were isolated by fluorescence-activated cell sorting (FACS) based on CD11b

Indexed as

CerebellumMicrogliaNicotineProteomeAdaptation, PhysiologicalAnimalsFemaleMaleMiceMice, Inbred C57BLProteomicsNicotineProteomeaddictioninflammationneurodegenerationsex differencessmoking

Identifiers

PMID41911483
PMCPMC13140143

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.