Evidence map›Paper›PMID 41911460›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Temporal neuronal differentiation programs safeguard neuronal diversity.

Dan Shen, Jingyi Chu, Xiaolin Zhou, Zejun Lan, Rulan Zhang, Shuyu Wang, Haoxuan Tang, Yunrui Wang, Chenlei Hu, Zhiyuan Li and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dan Shen *State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China.
Jingyi Chu *State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China.ORCID 0009-0009-8784-2756
Xiaolin Zhou *Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
Zejun LanState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China.ORCID 0009-0003-1544-3760
Rulan ZhangState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China.
Shuyu WangState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China.
Haoxuan TangState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China.ORCID 0009-0006-2939-8173
Yunrui WangState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China.ORCID 0009-0000-4197-3886
Chenlei HuState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China.ORCID 0009-0002-8145-5623
Zhiyuan LiPeking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.ORCID 0000-0001-6662-2636
Yan SongState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China.ORCID 0000-0002-1413-6123

Funding

the Ministry of Science and Technology of China 2022YFA1303100the National Natural Science Foundation of China 31771629the National Natural Science Foundation of China 32371024the Peking-Tsinghua Center for Life Sciences NAthe State Key Laboratory of Membrane Biology NA
6 · The paper itself

Abstract

Differentiation programs actively lock neurons into a terminally differentiated state. How differentiation programs operate in distinct neuronal lineages remains obscure. Here, we found that previously well-characterized

Indexed as

Cell DifferentiationDrosophila melanogasterDrosophila ProteinsNeurogenesisNeuronsAnimalsBrainGene Expression Regulation, DevelopmentalTCF Transcription FactorsTranscription FactorsDrosophila ProteinsTCF Transcription FactorsTranscription FactorsdedifferentiationDrosophila melanogasterneuronal differentiationneuronal diversitytemporal transcription factors

Identifiers

PMID41911460
PMCPMC13056081

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.