ArticleProceedings of the National Academy of Sciences of the United States of America2026
Biomechanical anticoagulation by spherical platelets in extracorporeal systems.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Review
- Biomechanical anticoagulation by spherical platelets in extracorporeal systems.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
Extracorporeal life support, such as hemodialysis, often face the risk of blood coagulation, where systemic anticoagulation with heparin is routinely administered. However, this strategy is contraindicated in patients at high risk of bleeding. Inspired by the observation that rolling motion of spherical platelets avoids their exposure to tangential forces, an anticoagulation strategy is proposed based on platelet spherification for extracorporeal systems. Experimental results prove that spherical platelets retain activation pathways and capacity compared to discoid platelets. Mechanical activation is driven by tangential rather than normal forces, and maintaining rolling instead of sliding effectively prevents tangential force-induced activation. Molecular dynamics simulations reveal that tangential force acting on sliding discoid platelets separates the integrin
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