Evidence map›Paper›PMID 41911295›Full record

ArticlePLoS neglected tropical diseases2026

Assessment of the role of Haemophilus ducreyi coinfection on outcomes of Yaws treatment in the southwestern part of Ghana.

Abigail Agbanyo, Michael Ntiamoah Oppong, Dzifa Kofi Ahiatrogah, Ruth Dede Tuwor, Clement Tettey, Joseph Azabire, Owusu Boakye Yiadom, Dennis Odai Laryea, Alex Owusu-Ofori, Richard Odame Phillips and 1 more

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Article in PLoS neglected tropical diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Abigail AgbanyoKumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Michael Ntiamoah OppongKumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Dzifa Kofi AhiatrogahKumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Ruth Dede TuworKumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Clement TetteyGhana Health Service, Sekondi, Ghana.
Joseph AzabireWassa Amenfi East District Health Directorate, Ghana Health Service, Wassa Akropong, Ghana.
Owusu Boakye YiadomAowin District Health Directorate, Ghana Health Service, Enchi, Ghana.
Dennis Odai LaryeaDisease Surveillance Department, Ghana Health Service, Accra, Ghana.
Alex Owusu-OforiSchool of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Richard Odame PhillipsKumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Yaw Ampem AmoakoKumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.ORCID https://orcid.org/0000-0002-4642-789X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundYaws, caused by Treponema pallidum subsp. pertenue (TP) is targeted for eradication by 2030 under the World Health Organization's (WHO) initiative, which relies on mass drug administration (MDA) of azithromycin. Evidence of persistent lesions after treatment has been reported. While the occurrences of Haemophilus ducreyi (HD) in yaws-like lesions has been widely documented, there is limited evidence regarding its influence on treatment outcomes assessed at the WHO-recommended 4-week follow-up. In this study, we sought to detect the occurrence of H. ducreyi in yaws-confirmed cases and assess its influence on treatment outcomes. METHODOLOGY: We conducted a prospective cohort study of school children from Wassa Amenfi East and Aowin Districts in Ghana. A total of 46 Dual Path Platform (DPP) positive yaws cases were subjected to PCR analysis to determine the aetiological agents, including T. pallidum and/or H. ducreyi. Treatment was with a single dose of oral azithromycin and outcomes were evaluated 4 weeks post-treatment, assessing clinical resolution and time to healing, with results stratified by the identified aetiological agents.

findingsOf the 46 participants tested, 18/46 (39%) were positive for HD, 6 (13%) were TP positive, 3 (7%) were positive for TP/HD, and 19 (41%) were negative for both pathogens tested. Healing rate was 80.4% (95% Confidence Interval [CI], 73.9-95.5) for all cases; 72.2% (95% CI: 57.0-93.4) for HD only, 83.3% (95% CI: 43.6-97.0) for TP only, 100% (95% CI: 43.9-100) for TP/HD, and 84.2% (95% CI: 62.4-94.5) for negative cases. Complete healing was generally observed by day 15-20.

conclusionThese results support the ongoing use of a single dose azithromycin in yaws elimination programmes, as evidenced by the healing rates observed. Nonetheless, greater focus should be directed toward improving diagnostic and treatment approaches for individual patients. Further research is necessary to better understand the aetiology of cutaneous ulcers in yaws-endemic regions.

Indexed as

Anti-Bacterial AgentsAzithromycinChancroidCoinfectionHaemophilus ducreyiYawsAdolescentChildFemaleGhanaHumansMaleProspective StudiesTreatment OutcomeTreponemaTreponema pallidumAnti-Bacterial AgentsAzithromycin

Identifiers

PMID41911295
PMCPMC13046261

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.