Trial reportPloS one2026
Preoperative binaural beats reduce remimazolam dosage and enhance safety in anesthesia induction: A randomized controlled trial.
Trial report in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06099977 (The Effect of Preoperative Binaural Sound on Remimazolam Dose Required for Induction of General Anesthesia), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Preoperative Binaural Sound on Remimazolam Dose Required for Induction of General Anesthesia: a Randomized, Placebo-controlled Trial
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Binaural beats, a form of auditory stimulation, are thought to reduce anxiety and anesthetic requirements through brainwave entrainment. Remimazolam offers advantages in terms of rapid onset and offset of action and hemodynamic stability. However, the optimal remimazolam dose for anesthesia induction remains unclear and there are concerns regarding variability in response and potential side effects at higher doses. This study investigated the effects of preoperative binaural beats on the remimazolam dose required for loss of consciousness during general anesthesia induction. In this randomized, prospective, single center study, 72 patients undergoing general anesthesia were allocated to two groups: the binaural sound (B group) or the control group. The B group listened to binaural sounds (1-Hz frequency difference) for 30 min preoperatively, while the control group did not. The B group required a significantly lower remimazolam dose for loss of consciousness (15.0 ± 3.6 vs. 17.7 ± 4.5 mg, p = 0.006) and achieved loss of consciousness faster (140 ± 29 vs. 168 ± 47 s, p = 0.003) than the control group. The incidence of hypotension was lower in the B group than in the control group (6 vs. 28%, p = 0.024). Electroencephalography spectral analysis revealed no significant between-group differences. Binaural beats significantly reduced the remimazolam dose required for loss of consciousness and shortened the time to loss of consciousness, while reducing the incidence of hypotension during anesthesia induction. Binaural beats are an effective, non-invasive method of enhancing efficiency and safety in anesthesia induction when using remimazolam infusion. Trial registration ClinicalTrials.gov NCT06099977.
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