ArticleBioconjugate chemistry2026
Prostate Stem Cell Antigen-Targeted DNA Aptamer Probe with Ultrahigh Tumor Contrast for Precision Fluorescence-Guided Surgery of Prostate Cancer.
Article in Bioconjugate chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Fluorescence-guided surgery (FGS) offers a potential strategy to improve complete tumor resection in prostate cancer (PCa); however, clinical application has been limited by an insufficient tumor-to-background ratio (TBR) of available probes. Here, we report the development of GGA-sNIR, a near-infrared (NIR) fluorescent probe engineered by conjugating a high-affinity DNA aptamer specific for a prostate stem cell antigen (PSCA) with a monocarboxy indocyanine green (ICG) derivative. The conjugate adopts a stable three-dimensional structure that not only enables precise target recognition but also protects against nuclease degradation, markedly enhancing its in vivo stability. GGA-sNIR exhibits nanomolar binding affinity (
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