SynthesisNeonatology2026
Pulmonary Hypertension Association with Mortality in Newborns with Giant Omphalocele: A Systematic Review and Meta-Analysis.
Synthesis in Neonatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pulmonary Hypertension Association with Mortality in Newborns with Giant Omphalocele: A Systematic Review and Meta-Analysis.Neonatology · 2026Pooled it
- Postoperative Pulmonary Hypertension after Primary Abdominal Wall Closure for Small Omphalocele: A Case Series.European journal of pediatric surgery reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPulmonary hypertension (PH) is associated with adverse outcomes in infants with omphalocele, but existing studies are limited by small sample sizes and single-center designs. This meta-analysis evaluated the association between PH and mortality, as well as secondary clinical outcomes.
methodsA systematic search in MEDLINE, EMBASE, and Cochrane CENTRAL identified studies of patients with giant omphalocele stratified by PH status. Eligible studies included nonrandomized cohorts, cross-sectional studies, or case controls assessing mortality in this setting. Exclusions were overlapping populations or incomplete data. Primary outcome was mortality. Secondary outcomes included duration of mechanical ventilation (MV), length of hospital and neonatal intensive care unit stay, parenteral nutrition, tracheostomy, high-frequency ventilation, and home oxygen. The risk of bias was assessed using the Newcastle-Ottawa Scale. The study protocol was registered in PROSPERO (CRD420251025073), and there was no funding for this study.
resultsOf 238 studies screened, five retrospective cohorts met criteria, totaling 258 patients (112 [43%] with PH and 146 [57%] without). PH was associated with increased mortality (OR: 6.78, 95% CI: 2.72-16.88, p < 0.001, I2 = 0%) and prolonged MV (mean difference 21.25 days, 95% CI: 13.19-29.31, p < 0.001, I2 = 0%). Limitations included publication bias, incomplete reporting of clinical variables, and the lack of standardized criteria.
conclusionPH in neonates with omphalocele is associated with higher mortality and prolonged MV. Future studies should clarify risk factors and develop targeted management strategies to improve survival and long-term outcomes.
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