Evidence map›Paper›PMID 41910801›Full record

ReviewAnnals of hematology2026

Case report: anti-GAD65 antibody-associated epilepsy as the primary manifestation of chronic graft-versus-host disease.

Suge Yang, Pengchen Gu, Jingluan Tian, Xiaowen Tang, Qun Xue

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Suge Yang *Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Pengchen Gu *Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Jingluan TianDepartment of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Xiaowen TangDepartment of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. xwtang1020@163.com.
Qun XueDepartment of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. qxue_sz@163.com.

Funding

The Soochow University Collaborative Innovation Center Research Project H240669
6 · The paper itself

Abstract

Central nervous system involvement in chronic graft-versus-host disease (CNS-cGVHD) is rare. This case report describes a young man who developed anti-glutamic acid decarboxylase 65 (GAD65) antibody-associated epilepsy after undergoing matched sibling donor hematopoietic stem cell transplantation. The therapeutic approach included intensive immunotherapy with methylprednisolone, immunoadsorption, Rituximab, and low-dose Daratumumab, in combination with four antiepileptic drugs and mycophenolate mofetil. This regimen led to a marked reduction in anti-GAD65 titers and an improvement in the NHS3 seizure severity score, decreasing from 8 to 3. Additionally, a review of the literature on post-transplant autoimmune encephalitis is also provided.

Indexed as

AutoantibodiesEpilepsyGlutamate DecarboxylaseGraft vs Host DiseaseHematopoietic Stem Cell TransplantationAdultChronic DiseaseHumansMaleRituximabAutoantibodiesGlutamate Decarboxylaseglutamate decarboxylase 2Rituximabanti-GAD65 antibody-associated epilepsycase reportchronic graft-versus-host diseaseDaratumumabimmunoadsorptionRituximab

Identifiers

PMID41910801
PMCPMC13035869

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.