Evidence map›Paper›PMID 41910746›Full record

ArticleNanoscale horizons2026

Regenerative bone-targeted nanoparticles modulate osteoclast function.

Vignesh K Rangasami, Cameron J Moore, Baixue Xiao, Danielle S W Benoit

Abstract read
In one paragraph

Article in Nanoscale horizons, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vignesh K RangasamiDepartment of Bioengineering, Phil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, USA. dbenoit@uoregon.edu.ORCID http://orcid.org/0000-0001-8151-5310
Cameron J MooreDepartment of Bioengineering, Phil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, USA. dbenoit@uoregon.edu.ORCID http://orcid.org/0009-0005-2768-1357
Baixue XiaoDepartment of Biomedical Engineering, University of Rochester, Rochester, NY 14623, USA.
Danielle S W BenoitDepartment of Bioengineering, Phil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, USA. dbenoit@uoregon.edu.ORCID http://orcid.org/0000-0001-7137-8164

Funding

DEVELOPMENTAL BIOLOGY TRAINING PROGRAMT32HD007348 · NICHD · UNIVERSITY OF OREGON · PI Chris Q Doe, KRYN STANKUNAS · 1989 to 2026
$6.8M
Tissue Engineering Strategies to Revitalize Bone AllograftsR01AR064200 · NIAMS · UNIVERSITY OF ROCHESTER · PI Danielle S. Benoit · 2013 to 2026
$4.0M
Bone-Targeted Nanoparticles to Accelerate Fracture Healing in Aging PopulationsUG3AG097136 · NIA · UNIVERSITY OF OREGON · PI BENOIT, DANIELLE S., ELISEEV, ROMAN · 2025 to 2025
$886k
Bone-targeted polymer therapeutics for nonunion fracture healingR21AG072692 · NIA · UNIVERSITY OF ROCHESTER · PI BENOIT, DANIELLE S. · 2022 to 2023
$406k
Tendon TRAP: Targeted Therapeutic Delivery to Enhance Tendon HealingR21AR081063 · NIAMS · UNIVERSITY OF ROCHESTER · PI BENOIT, DANIELLE S., LOISELLE, ALAYNA · 2022 to 2023
$373k
NIAMS NIH HHS R01 AR064200NIAMS NIH HHS R21 AR081063NIA NIH HHS R21 AG072692NIA NIH HHS UG3 AG097136NICHD NIH HHS T32 HD007348
6 · The paper itself

Abstract

Osteoclasts are vital for maintaining bone health. Indeed, dysregulated osteoclast activity is linked to pathological conditions such as Paget's disease, osteoporosis, and impaired fracture healing. Despite their importance in bone regeneration, few biomaterial-based strategies have been developed to alter osteoclast recruitment, differentiation, activity, or crosstalk with osteoblasts. To improve bone healing, we previously developed a drug delivery system (DDS) that expedites fracture repair. The DDS is composed of poly(styrene-

Indexed as

Bone RegenerationNanoparticlesOsteoclastsAnimalsCell DifferentiationFracture HealingMiceOsteogenesisPeptidesTartrate-Resistant Acid PhosphatasePeptidesTartrate-Resistant Acid Phosphatase

Identifiers

PMID41910746
PMCPMC13034928

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.