Evidence map›Paper›PMID 41910604›Full record

ArticleChemical research in toxicology2026

New Mechanistic Evidence for Perfluorodecanoic Acid (PFDA) Teratogenicity via CYP26A1-Mediated Retinoic Acid Metabolism and Signaling.

Michaela Hvizdak, Sylvie E Kandel, Jed N Lampe

Abstract read
In one paragraph

Article in Chemical research in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michaela HvizdakDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy, University of Colorado, Aurora, Colorado 80045, United States.ORCID 0009-0007-2249-5496
Sylvie E KandelDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy, University of Colorado, Aurora, Colorado 80045, United States.ORCID 0000-0002-8059-8035
Jed N LampeDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy, University of Colorado, Aurora, Colorado 80045, United States.ORCID 0000-0003-0794-2263

Funding

Understanding the underlying toxicological mechanisms of drug-hormone interactions to improve the safety profile of antiviral medications in pregnant people, developing fetuses, and neonatesR01AI183687 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Jed Noah Lampe · 2024 to 2026
$1.7M
NIAID NIH HHS R01 AI183687
6 · The paper itself

Abstract

Craniofacial abnormalities account for roughly one-third of all congenital birth defects worldwide. A growing body of evidence suggests that

Indexed as

Cytochrome P-450 Enzyme SystemDecanoic AcidsFluorocarbonsRetinoic Acid 4-HydroxylaseSignal TransductionTeratogensTretinoinAnimalsFemaleHumansPregnancyCYP26A1 protein, humanCytochrome P-450 Enzyme SystemDecanoic AcidsFluorocarbonsperfluorodecanoic acidRetinoic Acid 4-HydroxylaseTeratogensTretinoin

Identifiers

PMID41910604
PMCPMC13100982

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.