Evidence map›Paper›PMID 41910440›Full record

SynthesisScience progress

Extracellular vesicle therapies in regenerative endodontic procedures: A systematic review and meta-analysis of in vivo studies.

Madina A Kurmanalina, Nader Tanideh, Amin Tamadon, Aruzhan M Aitmukhanbetova, Nadiar M Mussin, Maryam Mardani, Mahdi Mahdipour, Shahrokh Zare, Ramazon Safarzoda Sharoffidin

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Madina A KurmanalinaStem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Nader TanidehStem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Amin TamadonStem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID 0000-0002-0222-3035
Aruzhan M AitmukhanbetovaDepartment of Dental Disciplines With Maxillofacial Surgery, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Nadiar M MussinDepartment of General Surgery, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Maryam MardaniOral and Dental Disease Research Center, Department of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Mahdi MahdipourStem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Shahrokh ZareStem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Ramazon Safarzoda SharoffidinState Educational Institution, Avicenna Tajik State Medical University, Dushanbe, Tajikistan.ORCID 0000-0001-9304-6945

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ObjectiveTo systematically review and quantitatively synthesize in vivo evidence on extracellular vesicle (EV)-based therapies for regenerative endodontic procedures, focusing on mineralization and angiogenesis outcomes.MethodsWe conducted a systematic review and meta-analysis of in vivo preclinical dentoalveolar/regenerative endodontic models comparing EV-based interventions (exosomes/microvesicles/apoptotic bodies), alone or with scaffolds, versus control conditions. Searches were performed in Web of Science Core Collection and Scopus from inception to 31 December 2025, with reference screening. Random-effects meta-analyses pooled standardized mean differences (SMDs) for mineralization and angiogenesis; heterogeneity was assessed using I

Indexed as

Extracellular VesiclesRegenerative EndodonticsAngiogenesisAnimalsHumansNeovascularization, PhysiologicRegenerationangiogenesisdental pulpExtracellular vesiclesodontogenesisregenerative endodontics

Identifiers

PMID41910440
PMCPMC13039592

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.