Evidence map›Paper›PMID 41910388›Full record

ArticlemBio2026

The transcriptional repressor Ssn6 modulates phase separation to regulate fungal gene expression.

Maureen A Dowell, Mae I Staples, Corey Frazer, Richard J Bennett

Abstract read
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maureen A DowellDepartment of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA.
Mae I StaplesDepartment of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA.
Corey FrazerDepartment of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA.ORCID 0000-0002-7660-6610
Richard J BennettDepartment of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA.ORCID 0000-0001-7563-484X

Funding

The role of Sirtuins in neurodegenerative diseaseP20GM109035 · NIGMS · BROWN UNIVERSITY · PI RAND, DAVID M · 2016 to 2025
$22.6M
Transcriptional Regulation of C. albicans Cell Fate and Host InteractionsR01AI081704 · NIAID · BROWN UNIVERSITY · PI Richard John Bennett · 2010 to 2026
$6.4M
Genetic Regulation of Heritable Switching in Candida albicansR01AI141893 · NIAID · BROWN UNIVERSITY · PI BENNETT, RICHARD JOHN · 2019 to 2023
$2.7M
The role of phase separation in a transcriptional repression mechanism relevant to Candida albicanspathogenesis.F31DE032591 · NIDCR · BROWN UNIVERSITY · PI DOWELL, MAUREEN · 2022 to 2023
$96k
NIAID NIH HHS R01 AI081704NIAID NIH HHS R01 AI141893NIDCR NIH HHS F31 DE032591NIGMS NIH HHS P20 GM109035
6 · The paper itself

Abstract

The transcriptional regulation of cell fate plays a central role in eukaryotic cell differentiation. In the human fungal pathogen

Indexed as

Candida albicansFungal ProteinsGene Expression Regulation, FungalRepressor ProteinsPhase SeparationProtein DomainsTranscription FactorsFungal ProteinsRepressor ProteinsTranscription Factorscorepressorsepigeneticphase separationtranscription

Identifiers

PMID41910388
PMCPMC13170171

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.