Evidence map›Paper›PMID 41910361›Full record

ArticlemBio2026

HIV Nef-mediated WAVE2-ARP2/3 inhibition underlies CD4

Daniel C Dunn, Jacqueline M Crater, Perla M Del Río Estrada, Jeffrey M Malgady, Griffin Haas, William Klain, Maria Fernanda Torres-Ruiz, Yara Andrea Luna-Villalobos, Mauricio González-Navarro, Chris Kang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Daniel C DunnFeinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA.
Jacqueline M CraterDivision of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
Perla M Del Río EstradaCentro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.
Jeffrey M MalgadyFeinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA.
Griffin HaasDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-2517-1071
William KlainDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Maria Fernanda Torres-RuizCentro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.
Yara Andrea Luna-VillalobosCentro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.
Mauricio González-NavarroCentro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.
Chris KangAbiosciences, South San Francisco, California, USA.
Colin KovacsMaple Leaf Medical Clinic, Toronto, Ontario, Canada.
Santiago Ávila-RíosCentro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.
Benhur LeeDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0003-0760-1709
Paul JolicoeurClinical Research Institute of Montreal, Montreal, Quebec, Canada.
Douglas F NixonFeinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA.ORCID 0000-0002-2801-1786
Robert L Furler O'BrienFeinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA.ORCID 0000-0001-5706-4871

Funding

Elucidating single cell changes in neurogenic brain regions during HIV and cannabinoid exposureU01DA058527 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Michael Jay Corley, Lishomwa C Ndhlovu · 2023 to 2026
$9.4M
Development of Brain Organoids to Study the Impact of HIV-1, Drugs of Abuseand Aging on Cognitive ImpairmentR01DA052027 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI NIXON, DOUGLAS F · 2020 to 2024
$3.7M
National Institute of Allergy and Infectious Diseases UM1-AI164559NCI NIH HHS R01-CA260691NIDA NIH HHS R01 DA052027NIDA NIH HHS R01-DA063076NIDA NIH HHS U01 DA058527
6 · The paper itself

Abstract

CD4 IMPORTANCE: CD4

Indexed as

Actin-Related Protein 2-3 ComplexCD4-Positive T-LymphocytesHIV-1nef Gene Products, Human Immunodeficiency VirusPseudopodiaWiskott-Aldrich Syndrome Protein FamilyActin CytoskeletonCells, CulturedHIV InfectionsHumansActin-Related Protein 2-3 Complexnef Gene Products, Human Immunodeficiency Virusnef protein, Human immunodeficiency virus 1WASF2 protein, humanWiskott-Aldrich Syndrome Protein FamilyactinARP2/3CD4+ T cellcell morphologycytoskeletonHIVmTORNefP-REX1primary immunodeficienciestime-lapse imagingWAVE2Wiskott-Aldrich syndrome

Identifiers

PMID41910361
PMCPMC13170354

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.