Eating behaviour profiles across the frontotemporal dementia spectrum.

Altered eating behaviours are a hallmark of behavioural variant frontotemporal dementia (bvFTD) but are less well characterised in progressive nonfluent aphasia (PNFA) and semantic dementia (SD). We investigated the frequency and onset of eating behaviour changes across the three subtypes. We retrospectively reviewed the data of 58 patients (14 bvFTD, 30 PNFA and 14 SD). The presence and onset of eating changes were assessed using the Neuropsychiatric Inventory and medical records. Eating behaviours were categorised into overeating, reduced food intake and food preference change. Primary outcomes were prevalence and incidence rates from the initial disease symptoms. A time-to-event analysis was used to compare the cumulative incidence of eating behaviour changes; cumulative incidence curves were estimated using the Kaplan-Meier method; and group differences were assessed using the log-rank test. Although the prevalence of eating changes was the highest in bvFTD (85.7%), followed by PNFA (63.3%) and SD (57.1%), the differences were not statistically significant (p = .220). Incidence also did not differ significantly (p = .054). However, overeating was significantly more frequent in the bvFTD group than in the PNFA and SD groups (p = .011). Changes in appetite and eating behaviour are common across the frontotemporal dementia spectrum and are not limited to bvFTD. Although the overall prevalence is similar across subtypes, overeating is specifically observed in bvFTD, whereas reduced food intake and food preference changes occur non-specifically.