Microgravity effects on secondary metabolism of plant-affecting bacteria.

Gayatri Sharma, Mohammed M A Ahmed, Tahir Ali, Paul D Boudreau, Patrick D Curtis

Abstract read

In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gayatri SharmaDepartment of Biology, University of Mississippi, University, Mississippi, USA.ORCID 0009-0004-4531-4000

Mohammed M A AhmedDepartment of BioMolecular Sciences, University of Mississippi, University, Mississippi, USA.

Tahir AliDepartment of BioMolecular Sciences, University of Mississippi, University, Mississippi, USA.

Paul D BoudreauDepartment of BioMolecular Sciences, University of Mississippi, University, Mississippi, USA.ORCID 0000-0001-5416-4404

Patrick D CurtisDepartment of Biology, University of Mississippi, University, Mississippi, USA.ORCID 0000-0002-4382-7564

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite their miniscule mass, microgravity has been shown to impose physiological stresses on bacteria, leading to altered gene regulation and metabolic output in unpredictable ways. Changes in metabolic output can ultimately impact the production of bacterial secondary metabolites. While a few studies have explored the changes in bacterial secondary metabolites under simulated or spaceflight microgravity, the specific area of plant-beneficial compound production by bacteria remains largely unexplored in these contexts. In this study, the production of metabolites pyoluteorin, 2,4-diacetylphloroglucinol (DAPG), orfamide A produced by the plant-promoting bacterium IMPORTANCE: Bacteria play an essential role in supporting plant health by producing antifungal compounds that protect against fungal diseases. In space, these bacterial functions may be disrupted. This study examined how microgravity affects the production of such compounds in plant beneficial bacteria,

Indexed as

biosynthetic gene clustersclinostatgenetic engineeringNASAsecondary metabolitessimulated microgravitytargeted metabolomicstranscriptomics

Identifiers

PMID41910142

DOI10.1128/spectrum.02239-25

PMCPMC13141840

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.