Evidence map›Paper›PMID 41910141›Full record

ArticleMicrobiology spectrum2026

lncRNA ch-MYC-AS1 restricts ALV-J replication by disrupting the ANXA2-C-Myc oncogenic axis.

Suyu Fan, Weiyi Zhou, Xuming Hu, Yingjie Gu, Guangzhong Peng, Yu Zhang, Wenming Zhao, Guohong Chen, Qi Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Suyu FanJiangsu Key Laboratory for Animal Genetic, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, China.
Weiyi ZhouSchool of Project Management, Faculty of Engineering, The University of Sydney, Sydney, New South Wales, Australia.
Xuming HuJiangsu Key Laboratory for Animal Genetic, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, China.ORCID 0000-0002-6973-8252
Yingjie GuJiangsu Key Laboratory for Animal Genetic, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, China.
Guangzhong PengJiangsu Key Laboratory for Animal Genetic, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, China.
Yu ZhangJiangsu Key Laboratory for Animal Genetic, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, China.
Wenming ZhaoJiangsu Key Laboratory for Animal Genetic, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, China.
Guohong ChenJiangsu Key Laboratory for Animal Genetic, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, China.
Qi XuJiangsu Key Laboratory for Animal Genetic, Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, China.ORCID 0000-0003-2791-0429

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The c-Myc oncogene is a critical regulator of viral oncogenesis and immune evasion in multiple cancers. However, its modulation by long noncoding RNAs (lncRNAs) during retroviral infection remains poorly understood. Here, we show that ch-MYC-AS1, a novel lncRNA, restricts avian leukosis virus subgroup J (ALV-J) replication by targeting c-Myc protein expression using chicken macrophage HD11 cells. Mechanistically, ch-MYC-AS1 binds to annexin A2 (ANXA2) and impedes its nuclear translocation, preventing its collaboration with c-Myc to promote glycolysis. This dual inhibition suppresses c-Myc-driven metabolic reprogramming essential for viral proliferation. Our findings reveal ch-MYC-AS1 as a key suppressor of retroviral replication through coordinated disruption of c-Myc/ANXA2 signaling, providing a potential therapeutic strategy for antiviral and anticancer drug development.IMPORTANCEAvian leukosis virus subgroup J (ALV-J) is an oncogenic retrovirus that causes tumors and immunosuppression in chickens, leading to significant economic losses in poultry industries. This study identifies a host-derived long noncoding RNA (lncRNA), ch-MYC-AS1, which suppresses ALV-J replication by disrupting the ANXA2-c-Myc signaling axis. These findings unveil a novel layer of antiviral defense mediated by an epigenetically regulated lncRNA and highlight a potential RNA-based strategy to combat retroviral infections. Moreover, targeting the ANXA2-c-Myc interaction may offer therapeutic insights for controlling ALV-J and other MYC-driven diseases.

Indexed as

ANXA2avian leukosis virusch-MYC-AS1oncogenic retrovirus

Identifiers

PMID41910141
PMCPMC13141950

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.