ArticleAnalytical chemistry2026
A Miniaturized Two-Electrode Detection System for Convenient and Rapid Ferricyanide-Mediated Chemical Toxicity Screening.
Article in Analytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
Toxicity bioassays play a crucial role in chemical risk assessment; however, conventional methods usually require specialized equipment, and limited accessibility is a significant drawback. Here, we present a user-friendly version using a simple two-electrode ferricyanide-mediated scaling of microbial respiration for rapid, convenient, and reliable toxicity assessment. The electrochemical cell is designed for continuous pulse-amperometric analysis, eliminating the need for disassembly/assembly and enabling a straightforward protocol to obtain a comprehensive evaluation of bacterial viability across a specific toxicant gradient in a single test run. Dose-response toxicity trends were directly observable, and half-maximal inhibitory concentration (IC
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