ArticlePsychological medicine2026
Life experiences of humiliation, entrapment, and frontoparietal-cerebellar connectivity predict adolescent anxiety and depression symptoms.
Article in Psychological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundExposure to major life stressors and aberrant brain functioning have been related to anxiety and depression in adolescence. However, whether these associations differ based on the specific characteristics of the stressors and/or brain functional networks remains unclear.
methodsIn a longitudinal sample of adolescents enriched for anxiety and depressive disorders, we examined cumulative lifetime stressor frequency and severity of five stressor characteristics: physical danger, interpersonal loss, humiliation, entrapment, and role change/disruption. Anxiety and depression symptoms were assessed at three time points: baseline, 6-month, and 12-month follow-ups. Linear mixed-effect models tested if lifetime frequency and severity of these stressor characteristics were associated with anxiety and depression symptoms across the three time points. We also identified whole-brain resting-state functional connectivity (RSFC) features linked to the predictive stressor characteristics and examined their associations with anxiety and depression symptoms across time.
resultsControlling for all other stressor characteristics and covariates, lifetime frequency and severity of humiliation and entrapment predicted greater anxiety and depression symptoms across the three time points. After additionally accounting for co-occurring depression and anxiety symptoms, only entrapment frequency and severity remained significant. More negative RSFC between the frontoparietal network and the left cerebellum were linked to greater entrapment severity at baseline, and associated with greater anxiety and depression symptoms across time.
conclusionsOur study highlights lifetime exposures to humiliation and entrapment as central stressor characteristics linked to adolescent internalizing symptoms. Our results also suggest that frontoparietal-left cerebellar connectivity may be a stress-sensitive marker of adolescent internalizing problems over time.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.