Evidence map›Paper›PMID 41909841›Full record

ArticleFrontiers in cellular and infection microbiology2026

C-terminus-outward orientation of SARS-CoV-2 envelope proteins on viral capsid enables a novel virus-cell interaction pathway.

Jie Xu, Wei Zhao, Yuanyuan Li, Jing Zheng, Yulian Wang, Huimin Sun, Sijin Wu, Baoqing Fu, Yiqiang Wang

Abstract read
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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jie XuEye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Wei ZhaoEye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Yuanyuan LiDepartment of Laboratory Examination, People's Hospital of Rizhao City, Rizhao, China.
Jing ZhengXiamen Center for Disease Control and Prevention, Xiamen, China.
Yulian WangEye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Huimin SunXiang'an Hospital of Xiamen University, Xiamen University, Xiamen, China.
Sijin WuWisdom Lake Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China.
Baoqing FuXiang'an Hospital of Xiamen University, Xiamen University, Xiamen, China.
Yiqiang WangEye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the onset of COVID-19, emphasis has been largely placed on spike proteins, while other molecules of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), such as the 78-aa-long envelope protein (E-pr), have been largely overlooked. This study was conducted to identify the orientation of E-pr in the envelope of the living SARS-CoV-2 virus and to confirm whether the viroid E-pr plays a role in the attachment and stimulation of the host cells. Using a customized antisera against the C-terminal half of E-pr (EC

Indexed as

Coronavirus Envelope ProteinsSARS-CoV-2Viral Envelope ProteinsAnimalsCOVID-19HumansHuman Umbilical Vein Endothelial CellsProtein BindingSpike Glycoprotein, CoronavirusVirus AttachmentCoronavirus Envelope Proteinsenvelope protein, SARS-CoV-2Spike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Viral Envelope ProteinsCOVID-19envelope proteinmicrobe-host interactionreceptorSARS-CoV-2

Identifiers

PMID41909841
PMCPMC13018128

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.