Evidence map›Paper›PMID 41909834›Full record

ArticlePsychoradiology2026

Impaired connectivity between the thalamus and the visual pathway in schizophrenia: a multimodal magnetic resonance imaging study.

Changyue Hou, Meihua Yan, Sisi Jiang, Yuting Deng, Lang Zhang, Hechun Li, Mingjun Duan, Yafeng Wang, Gang Yao, Hui He and 3 more

Abstract read
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In one paragraph

Article in Psychoradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Changyue HouThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, PR China.
Meihua YanThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, PR China.
Sisi JiangThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, PR China.
Yuting DengThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, PR China.
Lang ZhangDepartment of Psychiatry, The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu 610000, PR China.
Hechun LiThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, PR China.
Mingjun DuanThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, PR China.
Yafeng WangThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, PR China.
Gang YaoThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, PR China.
Hui HeThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, PR China.
Roberto Rodríguez-LabradaCuban Neuroscience Center, La Habana 11600, Cuba.
Dezhong YaoThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, PR China.ORCID https://orcid.org/0000-0002-8042-879X
Cheng LuoThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, PR China.ORCID https://orcid.org/0000-0003-0524-5886

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Schizophrenia is a severe psychiatric disorder characterized by cognitive deficits as well as positive and negative symptoms. It is considered a disorder of widespread network dysconnectivity, including aberrant connectivity between the thalamus and the visual pathway. However, the relationships between the thalamus and various regions of the dorsal and ventral visual pathways in schizophrenia, and how the thalamus affects interactions among these visual regions, remain unclear. Methods: Resting-state functional magnetic resonance imaging, task-state functional magnetic resonance imaging, and diffusion tensor imaging data were acquired to examine the neural activity within the thalamus and the visual pathway, along with the relationships between them (i.e. functional connectivity, structural connectivity, and structure-function coupling). We also correlated the altered imaging parameters with clinical characteristics. Furthermore, based on previous molecular imaging in healthy controls, we explored the spatial associations between altered imaging parameters and receptor/transporter distributions. Results: We found significantly decreased neural activity and widespread altered thalamo-visual pathway connectivity in both dorsal and ventral pathways in schizophrenia patients. Moreover, schizophrenia patients exhibited altered mediation effects within the thalamo-dorsal visual pathway, involving MT, V1, V2, and V3. Abnormal neural activity and connectivity were related to disease duration and positive symptom severity. Altered neural activity of MT was correlated with the density of multiple neurotransmitters. Conclusions: Our findings further expand our understanding of thalamo-visual pathway dysconnectivity and primary information-processing deficits in schizophrenia, which may be related to clinical symptoms. Our findings may provide more potential insights for non-invasive intervention treatments.

Indexed as

multimodal MRISchizophreniathalamo-visual pathway dysconnectivity

Identifiers

PMID41909834
PMCPMC13023046

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.