ArticleJournal of asthma and allergy2026
Sensitization to Dog Dander Allergen Can f 1 is Associated with Asthma Symptom Severity and Exacerbations in a Singapore-Malaysia Cohort.
Article in Journal of asthma and allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Background: Sensitization to pet dander allergens has been increasing globally, however, its clinical relevance to allergic disease exacerbation remains underexplored. Objective: We aimed to determine the prevalence of serum-specific IgE (SSIgE) response to the major dog allergen Patients and Methods: A comprehensive serological profiling of specific IgE responses to 38 common inhalant and seafood allergen sources was performed in 736 young adults from the Singapore/Malaysia Cross-sequential Genetics and Epidemiology Study (SMCGES) sub-cohort. SSIgE levels were analyzed in relation to asthma diagnosis, symptom frequency, and exacerbation history. Results: Detectable Can f 1-specific IgE was present in 13.5% of participants, predominantly at low-grade Class 1-2 levels (0.35-3.49 IU/mL). Individuals with pre-existing sensitization to common inhalant and seafood allergen sources, including house dust mites (HDM), cat dander ( Conclusion: Sensitization to Can f 1 is associated with increased asthma-related symptom burden and exacerbation risk, particularly in individuals with pre-existing atopy among young adults in Singapore and Malaysia. These findings highlight Can f 1-specific IgE as a potential molecular marker for identifying higher-risk asthma phenotypes in the tropical environment.
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