Evidence map›Paper›PMID 41909752›Full record

ArticleActa pharmaceutica Sinica. B2026

Vitamin A and its analogues modulate MUFAs metabolism to improve ferroptosis and aging by direct targeting of ACSL3.

Nanxuan Luo, Yijie Xiao, Yile Zhai, Jie Li, Lijie Lv, Houhua Yin, Fang Lin, Biwen Wan, Ke Zhang, Junchi Hu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Nanxuan LuoBasic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), Department of Cancer Center and Department of Urology of the Second Affiliated Hospital, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Yijie XiaoBasic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), Department of Cancer Center and Department of Urology of the Second Affiliated Hospital, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Yile ZhaiThe Second Hospital, Cheeloo College of Medicine, Shandong University, Ji'nan 250033, China.
Jie LiBasic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), Department of Cancer Center and Department of Urology of the Second Affiliated Hospital, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Lijie LvBasic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), Department of Cancer Center and Department of Urology of the Second Affiliated Hospital, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Houhua YinBasic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), Department of Cancer Center and Department of Urology of the Second Affiliated Hospital, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Fang LinBasic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), Department of Cancer Center and Department of Urology of the Second Affiliated Hospital, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Biwen WanBasic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), Department of Cancer Center and Department of Urology of the Second Affiliated Hospital, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Ke ZhangBasic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), Department of Cancer Center and Department of Urology of the Second Affiliated Hospital, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Junchi HuBasic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), Department of Cancer Center and Department of Urology of the Second Affiliated Hospital, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Junyan LiuBasic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), Department of Cancer Center and Department of Urology of the Second Affiliated Hospital, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Yongjun DangBasic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), Department of Cancer Center and Department of Urology of the Second Affiliated Hospital, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Yi HeBasic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), Department of Cancer Center and Department of Urology of the Second Affiliated Hospital, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Yahui ZhaoBasic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), Department of Cancer Center and Department of Urology of the Second Affiliated Hospital, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Zhe ZhangThe Second Hospital, Cheeloo College of Medicine, Shandong University, Ji'nan 250033, China.
Shenyou NieBasic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), Department of Cancer Center and Department of Urology of the Second Affiliated Hospital, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Hai-Xin YuanBasic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), Department of Cancer Center and Department of Urology of the Second Affiliated Hospital, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In our screening campaign for novel ferroptosis inhibitors, we identified that vitamin A (VA) and its metabolite all-

Indexed as

ACSL3Acute liver injuryAgingAll-trans retinoic acidFerroptosisLipid metabolismLongevityVitamin A

Identifiers

PMID41909752
PMCPMC13031062

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.