ArticleFrontiers in immunology2026
Venous endothelial remodeling mediated by
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Background: Hepatocellular carcinoma (HCC) is characterized by pronounced heterogeneity and extensive angiogenesis. However, anti-angiogenic therapies often show limited clinical benefit due to therapeutic resistance. Understanding endothelial cell heterogeneity and identifying key regulators of tumor angiogenesis are therefore essential for improving treatment strategies. Methods: We integrated multiple single-cell RNA sequencing (scRNA-seq) datasets to systematically characterize endothelial cell heterogeneity in the HCC microenvironment. Based on genes enriched in venous endothelial cells, we developed a prognostic risk model termed the Vein Endothelial-related Risk Scores (VERS). The functional role of the key gene Results: Venous endothelial cells (VenECs) were identified as key initiators of tumor angiogenesis in HCC. Among the VERS genes, Discussion: Our findings reveal a critical role for venous endothelial cells in HCC angiogenesis and identify
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