ReviewFrontiers in immunology2026
Tocilizumab in the treatment of IgG4-related disease involving the carotid artery-case report and literature review.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
IgG4-related disease (IgG4-RD) is an autoimmune disorder characterized by fibroinflammatory infiltration of affected organs. This systemic condition can involve multiple organs, including the pancreas, bile ducts, salivary glands, kidneys and lungs. However, IgG4-related disease demonstrates substantial heterogeneity and frequently involves atypical anatomical sites, leading to frequent clinical misdiagnosis. We report a rare case of IgG4-RD involving the carotid artery and vagus nerve, presenting with hoarseness and syncope. Diagnosis was confirmed via contrast-enhanced neck MRI and carotid artery biopsy. The patient exhibited poor response to glucocorticoids and methotrexate but achieved sustained remission following combination therapy with tocilizumab. A literature review revealed that isolated involvement of the carotid artery and vagus nerve in IgG4-RD is exceptionally rare.
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