ArticleFrontiers in immunology2026
Protective immunity against Chagas disease induced by a superantigen-based chimeric DNA vaccine delivered by attenuated
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Chagas disease is a chronic parasitic infection endemic to Latin America that affects more than 7 million people and is increasingly spreading worldwide due to human migration. Methods: Here, we evaluated the immunogenicity and protective efficacy of CruSEG using different vaccination strategies, including recombinant protein formulated with CpG-ODN,oral DNA immunization delivered by attenuated Results: All vaccination protocols induced Nt-Cz-specific immune responses, albeit with distinct qualitative profiles. Recombinant protein vaccination elicited robust humoral immunity characterized by Th1-skewed IgG2a responses and strong parasite neutralizing activity, whereas DNA delivery preferentially promoted potent cellular immunity, including polyfunctional CD4 Discussion-conclusions: Although sterilizing immunity was not achieved, the attenuation of parasite persistence and pathology represents a biologically relevant outcome. Collectively, these findings demonstrate that incorporating a detoxified bacterial superantigen into chimeric antigens across multiple platforms enhances immune quality and protective efficacy, highlighting engineered superantigens as promising immune modulators for the development of effective vaccines against Chagas disease.
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