Evidence map›Paper›PMID 41909636›Full record

ArticleJournal of sickle cell disease2026

Cerebral microhemorrhages in a mouse model of sickle cell disease.

Yu-Han Hung, Chuo Fang, Donghy Lee, Jiamin Yan, Stacy Kiven, Jihua Liu, Seung Min Kim, Annlia Paganini-Hill, David H Cribbs, Kalpna Gupta and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of sickle cell disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yu-Han HungDepartment of Neurology, University of California, Irvine, Orange, CA, 92868, United States.ORCID https://orcid.org/0000-0002-6466-9921
Chuo FangDepartment of Neurology, University of California, Irvine, Orange, CA, 92868, United States.ORCID https://orcid.org/0000-0002-2473-0951
Donghy LeeDepartment of Neurology, University of California, Irvine, Orange, CA, 92868, United States.ORCID https://orcid.org/0009-0003-5949-1115
Jiamin YanDepartment of Neurology, University of California, Irvine, Orange, CA, 92868, United States.ORCID https://orcid.org/0009-0004-8224-5593
Stacy KivenDivision of Hematology/Oncology, Department of Medicine, University of California, Irvine, Irvine, CA, 92697, United States.ORCID https://orcid.org/0000-0003-3681-309X
Jihua LiuInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, 92697, United States.ORCID https://orcid.org/0009-0008-5728-7061
Seung Min KimDepartment of Neurology, University of California, Irvine, Orange, CA, 92868, United States.ORCID https://orcid.org/0000-0001-5228-6512
Annlia Paganini-HillBeckman Laser Institute, University of California, Irvine, Irvine, CA, 92697, United States.ORCID https://orcid.org/0000-0003-4106-3334
David H CribbsInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, 92697, United States.ORCID https://orcid.org/0000-0002-6870-4480
Kalpna GuptaDivision of Hematology/Oncology, Department of Medicine, University of California, Irvine, Irvine, CA, 92697, United States.ORCID https://orcid.org/0000-0001-9381-9979
Mark FisherDepartment of Neurology, University of California, Irvine, Orange, CA, 92868, United States.ORCID https://orcid.org/0000-0001-9802-8826

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Stroke in sickle cell disease (SCD) is often attributed to large vessel involvement in the disorder, whereas the contribution of cerebral microvascular disease has been less explored. In this study, we investigated the formation of cerebral microvascular lesions and the involvement of mast cells in a humanized SCD mouse model. Methods: We studied hemorrhagic microvascular disease in a well-characterized mouse model of humanized transgenic sickle (HbSS-BERK) expressing >99% human sickle hemoglobin (HbS) and a control (HbAA-BERK) mouse model expressing normal human hemoglobin A (HbA). Mouse brains were analyzed by Prussian blue staining to detect cerebral microhemorrhage (CMH) formation. Mast cell identification was performed by toluidine blue staining. Results: SCD brain sections exhibited approximately 86% more CMH than controls (mean ± SE of 1.17 ± 0.22 vs. 0.63 ± 0.13 number/cm Conclusion: SCD mice demonstrated significantly increased CMH load compared with control mice, and SCD microhemorrhages were associated with the number of mast cells. These findings highlight the significance of cerebral microvascular disease in SCD and imply that cerebral mast cells may be a novel therapeutic target in SCD.

Indexed as

cerebral microhemorrhagesmast cellssickle cell diseasesmall vessel disease

Identifiers

PMID41909636
PMCPMC13020912

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.