ArticleInternational journal of general medicine2026
Non-HDL/HDL Cholesterol Ratio as a Protective Factor for Functional Recovery Following Intracerebral Hemorrhage: A Prospective Cohort Study.
Article in International journal of general medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Whether lipid profiles influence functional recovery after intracerebral hemorrhage (ICH) is unclear. This study investigated the association between the non-high-density lipoprotein to high-density lipoprotein cholesterol ratio (NHHR) and 90-day functional outcomes in patients with ICH. Patients and Methods: This single-center, prospective, observational cohort study enrolled 200 patients with acute ICH. Fasting blood samples were collected within 24 hours of admission for lipid profiling, and NHHR was calculated as (total cholesterol high-density lipoprotein cholesterol [HDL-C])/HDL-C. The primary outcome was functional status at 90 days, assessed using the modified Rankin Scale (mRS). Based on the mRS scores, patients were classified into two groups: favorable outcome (mRS ≤ 2, functional independence) and poor outcome (mRS > 2, functional dependence or death). Results: Of the 200 patients, 81 (40.5%) had poor outcomes at 90 days. The poor outcome group exhibited significantly lower baseline NHHR compared to the favorable outcome group (2.54 vs. 2.75, Conclusion: A higher baseline NHHR independently predicts favorable 90-day outcomes after ICH, supporting a "protective lipid paradox" distinct from ischemic stroke. As a simple and readily available biomarker, NHHR offers complementary prognostic information to established clinical scales and may aid early risk stratification.
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