Evidence map›Paper›PMID 41909512›Full record

ArticleBioactive materials2026

Adaptable sliding hydrogels enable pericellular pocket formation while enhancing MSC chondrogenesis and survival in 3D.

Sarah J Loveland, Xinming Tong, Manish Ayushman, Hung-Pang Lee, Julia M Johannsen, Callie M Weber, Jake Song, Michelle Tai, Georgios Mikos, Yara Chaib and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sarah J LovelandDepartment of Chemistry, Stanford University, 337 Campus Drive, Stanford, CA, 94305, United States.
Xinming TongDepartment of Orthopaedic Surgery, Stanford University, 300 Pasteur Drive, Palo Alto, CA, 94304, United States.
Manish AyushmanDepartment of Bioengineering, Stanford University, 443 Via Ortega, Stanford, CA, 94305, United States.
Hung-Pang LeeDepartment of Orthopaedic Surgery, Stanford University, 300 Pasteur Drive, Palo Alto, CA, 94304, United States.
Julia M JohannsenDepartment of Biology, Stanford University, 371 Jane Stanford Way, Stanford, CA, 94305, United States.
Callie M WeberDepartment of Orthopaedic Surgery, Stanford University, 300 Pasteur Drive, Palo Alto, CA, 94304, United States.
Jake SongDepartment of Mechanical Engineering, Stanford University, 440 Escondido Mall Building 530, Stanford, CA, 94305, United States.
Michelle TaiDepartment of Bioengineering, Stanford University, 443 Via Ortega, Stanford, CA, 94305, United States.
Georgios MikosDepartment of Chemical Engineering, Stanford University, 443 Via Ortega Shriram Center, Stanford, CA, 94035, United States.
Yara ChaibDepartment of Orthopaedic Surgery, Stanford University, 300 Pasteur Drive, Palo Alto, CA, 94304, United States.
Ovijit ChaudhuriDepartment of Mechanical Engineering, Stanford University, 440 Escondido Mall Building 530, Stanford, CA, 94305, United States.
Fan YangDepartment of Orthopaedic Surgery, Stanford University, 300 Pasteur Drive, Palo Alto, CA, 94304, United States.

Funding

Enhanced cartilage formation of chondrocytes in viscoelastic ECMs under mechanical loadingF32AR084286 · NIAMS · STANFORD UNIVERSITY · PI Hyuk Joon Jake Song · 2024 to 2026
$231k
NIAMS NIH HHS F32 AR084286
6 · The paper itself

Abstract

Hydrogels that recapitulate the dynamic mechanical cues of native extracellular matrix are powerful tools that can be leveraged for tissue engineering. Despite growing recognition that cues such as stress relaxation and plasticity modulate cell-matrix interactions, the influence of these properties on mesenchymal stromal cell (MSC) chondrogenesis has yet to be elucidated across a broad range of relaxation timescales and in the absence of confounding biochemical cues. Here, we report the adaptable sliding hydrogel (ASG) with tunable stress relaxation and plasticity as a novel MSC cell niche. By incorporating reversible hydrazone crosslinks into polyethylene glycol (PEG)-based sliding hydrogels (SG), ASG achieves a wide range of tunable stress relaxation and plasticity that are distinct from other dynamic hydrogels used for MSC chondrogenesis. Notably, increasing stress relaxation and plasticity in ASG promotes rapid and robust cartilage formation by human MSCs and supports long-term cell viability. Mechanistically, ASG facilitates local matrix remodeling and enables MSCs to form "pericellular pockets" in 3D that correlate with enhanced nascent extracellular matrix deposition and reorganization, integrin signaling, and nuclear dynamics. Overall, the ASG platform provides a tunable, synthetic microenvironment that helps probe the relationship between dynamic mechanical cues and stem cell fate and informs next-generation material design within the field of tissue engineering.

Indexed as

ChondrogenesisDynamicHydrogelsMechanotransductionViscoelasticity

Identifiers

PMID41909512
PMCPMC13019076

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.