Evidence map›Paper›PMID 41909454›Full record

ArticleJournal of veterinary science & medical diagnosis2019

New Zealand White Rabbits Fed High Cholesterol Diets Develop Morbid Systemic Diseases before Intracranial Atherosclerosis is Detected.

M S Zabriskie, S Wang, S E Kim, J S McNally, A H de Havenon, D L Parker, M D Alexander

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of veterinary science & medical diagnosis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Spatially resolved transcriptomics for evaluation of intracranial vessels in a rabbit model: Proof of concept.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2023
    Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

M S ZabriskieDepartment of Radiology and Imaging Sciences (MSZ, SW, SEK, JSM, DLP, MDA), Neurosurgery (MDA), and Neurology (AHD), University of Utah, Salt Lake City, Utah, USA.
S WangDepartment of Radiology and Imaging Sciences (MSZ, SW, SEK, JSM, DLP, MDA), Neurosurgery (MDA), and Neurology (AHD), University of Utah, Salt Lake City, Utah, USA.
S E KimDepartment of Radiology and Imaging Sciences (MSZ, SW, SEK, JSM, DLP, MDA), Neurosurgery (MDA), and Neurology (AHD), University of Utah, Salt Lake City, Utah, USA.
J S McNallyDepartment of Radiology and Imaging Sciences (MSZ, SW, SEK, JSM, DLP, MDA), Neurosurgery (MDA), and Neurology (AHD), University of Utah, Salt Lake City, Utah, USA.
A H de HavenonDepartment of Radiology and Imaging Sciences (MSZ, SW, SEK, JSM, DLP, MDA), Neurosurgery (MDA), and Neurology (AHD), University of Utah, Salt Lake City, Utah, USA.
D L ParkerDepartment of Radiology and Imaging Sciences (MSZ, SW, SEK, JSM, DLP, MDA), Neurosurgery (MDA), and Neurology (AHD), University of Utah, Salt Lake City, Utah, USA.
M D AlexanderDepartment of Radiology and Imaging Sciences (MSZ, SW, SEK, JSM, DLP, MDA), Neurosurgery (MDA), and Neurology (AHD), University of Utah, Salt Lake City, Utah, USA.

Funding

Improved imaging of carotid plaque using high-resolution, motion-corrected 3D MRIR01HL127582 · NHLBI · UNIVERSITY OF UTAH · PI PARKER, DENNIS L · 2016 to 2019
$2.3M
Siemens MAGNETOM Prisma 3T MRI scannerS10OD018482 · OD · UNIVERSITY OF UTAH · PI PARKER, DENNIS L · 2015 to 2015
$1.2M
Treatment Targets for Inflamed Intracranial Atherosclerosis on Vessel Wall MRIK23NS105924 · NINDS · YALE UNIVERSITY · PI DE HAVENON, ADAM H. · 2019 to 2023
$988k
NHLBI NIH HHS R01 HL127582NIH HHS S10 OD018482NINDS NIH HHS K23 NS105924
6 · The paper itself

Abstract

Intracranial atherosclerotic disease (ICAD) lacks sufficient human data; a suitable animal model is needed. Watanabe heritable hyperlipidemic (WHHL) rabbits have limitations for ICAD. New Zealand white (NZW) rabbits fed high cholesterol diets and WHHL rabbits were evaluated. 14 rabbits underwent evaluation with MRI and pathology. No NZW rabbits (8 fed high cholesterol diet, 2 fed regular diets) developed ICAD. 6 (75%) high-cholesterol rabbits did not survive for the planned timeframe. All 4 WHHL rabbits developed ICAD. Methods other than induction with a high cholesterol diet should be pursued for an ICAD model.

Indexed as

AtherosclerosisHyperlipidemiaNew Zealand whiteRabbit

Identifiers

PMID41909454
PMCPMC13021252

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.