ArticleCureus2026
Role of Advanced MRI-Based Perfusion and Diffusion Imaging in Predicting Recovery After the Surgical Management of Cervical Myelopathy: A Retrospective Study.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
backgroundCervical myelopathy is a common cause of non-traumatic spinal cord dysfunction, where both structural compression and microvascular compromise contribute to neurological deficits.
objectiveThis study aimed to evaluate the prognostic value of advanced MRI-based perfusion and diffusion parameters in predicting neurological recovery following surgical decompression in patients with cervical myelopathy. METHODOLOGY: This retrospective observational study was conducted at the Department of Neurosurgery, Punjab Institute of Neurosciences, Lahore, Pakistan, from September 2024 to September 2025 and included 105 patients with clinically and radiologically confirmed cervical myelopathy who underwent decompressive surgery. Preoperative MRI included diffusion tensor imaging (DTI)-derived parameters fractional anisotropy (FA), apparent diffusion coefficient (ADC), and intravoxel incoherent motion (IVIM) perfusion metrics true diffusion coefficient (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f). Results: The mean preoperative and postoperative Modified Japanese Orthopaedic Association (mJOA) scores were 10.4±2.3 and 14.9±1.8, respectively (p<0.001). FA showed a strong positive correlation with recovery rate (r=0.68; p<0.001), while ADC demonstrated a significant negative correlation (r=-0.59; p<0.001). Perfusion fraction also correlated positively with recovery (r=0.53; p<0.01). The receiver operating characteristic (ROC) analysis identified FA ≥0.41 and f ≥9.5% as optimal thresholds for predicting good recovery (area under the curve (AUC)=0.86 and 0.78, respectively). A combined FA+f model achieved the highest predictive accuracy (AUC=0.90).
conclusionIt is concluded that advanced MRI-based diffusion and perfusion imaging provides a reliable, quantitative method for predicting postoperative recovery in cervical myelopathy. FA and perfusion fraction are the most effective predictors of neurological improvement, offering superior prognostic value compared to conventional MRI.
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