ArticleCureus2026
Presumed Cytokine-Mediated Mild Liver Injury With Similar Kinetics Following COVID-19, Acute Prostatitis, and mRNA Vaccination: A Case Report and Review of the Literature.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Cytokine-mediated liver injury is well-documented in severe systemic inflammatory conditions, such as cytokine storms. However, its occurrence in mild inflammatory settings remains underrecognized and is rarely monitored longitudinally in a single individual. The author presents his own case involving recurrent episodes of transient, mild liver injury occurring in himself as a 72-year-old man. These episodes were temporally associated with three distinct inflammatory stimuli: COVID-19, acute prostatitis, and administration of a SARS-CoV-2 mRNA vaccine. Liver function tests performed during each event showed similar patterns of elevation followed by normalization. After mRNA vaccination, monitoring revealed a transient increase in proinflammatory cytokines, specifically IL-6 and tumor necrosis factor alpha, that coincided with the elevation of liver enzymes. The recurrence of this distinct pattern of mild liver injury suggests a potential host-specific predisposition to cytokine-mediated injury in response to various inflammatory stimuli. This observation warrants further investigation to clarify the pathophysiology and clinical significance of such mild reactions.
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