Evidence map›Paper›PMID 41909246›Full record

ArticleView (Beijing, China)2026

PSMA PET-directed radiotherapy for prostate cancer: From precision planning to future innovations.

Wenpeng Huang, Jessica C Hsu, Ruobing Li, Kexin Lan, Xin Qi, Yuchun Wei, Weibo Cai, Hongzhen Li

Abstract read
In one paragraph

Article in View (Beijing, China), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenpeng HuangDepartment of Nuclear Medicine, Peking University First Hospital, Beijing, China.
Jessica C HsuDepartments of Radiology and Medical Physics, University of Wisconsin - Madison, Madison, Wisconsin, USA.ORCID 0000-0002-3599-2834
Ruobing LiCollege of Letters and Science, University of Wisconsin - Madison, Madison, Wisconsin, USA.
Kexin LanDepartment of Nuclear Medicine, Peking University First Hospital, Beijing, China.
Xin QiDepartment of Radiation Oncology, Peking University First Hospital, Beijing, China.
Yuchun WeiDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong Province, China.
Weibo CaiDepartments of Radiology and Medical Physics, University of Wisconsin - Madison, Madison, Wisconsin, USA.
Hongzhen LiDepartment of Radiation Oncology, Peking University First Hospital, Beijing, China.

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
NCI NIH HHS P30 CA014520
6 · The paper itself

Abstract

Positron emission tomography (PET), particularly with prostate-specific membrane antigen (PSMA) tracers, has revolutionized the clinical management of prostate cancer (PCa). This review highlights the pivotal role of PET molecular imaging in guiding radiotherapy (RT) across diverse clinical scenarios, from postoperative biochemical recurrence to oligometastatic disease. Growing evidence shows that PET excels in lesion detection, enhances target volume delineation, enables focal dose escalation, and guides treatment intensification. PSMA PET increases the precision of RT planning, supports personalized therapeutic approaches, and is associated with improved outcomes, including biochemical recurrence-free and metastasis-free survival. The integration of PET with advanced RT technologies, including biology-guided radiotherapy (BgRT), is paving the way for real-time, biologically adaptive treatment paradigms. However, challenges remain, including the need for standardized protocols, management of tracer variability, and clinical translation of innovations such as PET-linear accelerator (LINAC) into routine practice. Future research should prioritize large-scale, prospective studies to establish the clinical efficacy, cost-effectiveness, and optimal integration of PET-guided RT in PCa care.

Indexed as

biology-guided radiotherapymetastatic diseasepersonalized medicinePET/CTprostate cancerPSMAradiation therapy

Identifiers

PMID41909246
PMCPMC13028602

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.